Key points
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要点
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Localized vitiligo usually stops its progression in 1-2 years after its first manifestation.
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•局限型白癜风通常在发病后 1 到 2 年停止 进展。
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•Generalized vitiligo is progressive in 73% of the cases.
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•73%的泛发型白癜风病例呈进展性。
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Administration of oral or intravenous corticosteroids may lead to
the cessation of disease progression in 85%
of cases.
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•85%的病例口服或静脉给予皮质类固醇激 素可停止疾病的进展。
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•Vitiligo progression could be stopped in 4 out of 5 cases by the use of potent systemic corticosteroids, but due to possible relevant side effects, the decision must be taken by expert dermatologists after careful evaluation.
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•4/5 白癜风病例可在系统应用皮质激素后 停止进展,但是由于存在相关副作用,系 统应用激素治疗必须由专业皮肤科医师仔 细评估后再采用。
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•Answer
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•解答
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Vitiligo is progressive in 73% of cases
and regressive in 1.3%.
We usually explain to the patients that progression depends on how the disease spreads: localized or generalized forms have different behavior. In 89%
of localized vitiligo
cases, disease activity ceases after 1-2 years of rapid
spreading over the affected skin area, while generalized vitiligo shows less progression only when it starts on the
face (52% of the cases).
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白癜风病例中,73%是进展的,1.3%是减退 的。通常,我们向患者解释其进展取决于疾
病累及范围:局限型和泛发型有不同的表 现。89%局限型白癜风的病例,在快速扩散
后 1-2 年活动性停止;52%泛发型白癜风病 例,如果皮损开始出现在面部时,其进展可 能性较小。
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In 89% of cases we can arrest patch extension in widespread vitiligo with oral minipulse corticosteroid therapy (5 mg
betamethasone on 2 consecutive days per week) . Use of corticosteroid methylprednisolone 8 mg/Kg
intravenously for 3 consecutive days in patients with generalized vitiligo led to temporary cessation to the disease progression in 85% of cases and repigmentation in 71% of cases. Other steroids used intravenously showed a similar degree of limiting
the disease progression.
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89% 的病例我们可通过口服小剂量激素治
疗(每周连续两天 5 毫克倍他米松)阻止广
泛扩散白癜风白斑的扩展。连续三天静脉应
用甲泼尼松(8mg/Kg)治疗泛发型白癜风, 可以使 85%患者疾病进展短暂停止和 71%病 例的复色。其他的类固醇激素静脉治疗显示 了相似的限制疾病进展的效果。
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