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Answer
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解答
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It is well-known that heredity is an issue
in vitiligo propensity. In fact, around 20% of people with vitiligo report about a first
degree relative as the one suffering from the same disorder. Children of a vitiligo affected subject have a 1.7-fold
increased risk of developing vitiligo compared with other family members. HLA haplotypes may contribute to generalized
vitiligo susceptibility, i.e.
HLAs
-A2, -DR4,
- DR7 and -DQB1 0303.
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众所周知，遗传是白癜风的一个易患因素。 约
20%的白癜风患者称他们一级亲属中有人 患有白癜风。白癜风患者的子女的白癜风患 病风险比其他家庭的子女增加了 1.7 倍。人
类白细胞抗原单倍型可能增加泛发型白癜 风的易感性，如 HLAs-A2，-DR4，-DR7and
-DQB1 0303。
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NALP-1 gene (NACHT
leucine rich- repeat protein 1) is a major susceptibility gene that is epidemiologically linked to generalized vitiligo
and other autoimmune diseases (i.e. thyroid disease, pernicious anemia, and
lupus erythematosus).
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NALP-1 基因（NACHT 富亮氨酸重复蛋白 1）， 从流行病学上来说，是与泛发型白癜风及其
他自身免疫病（如甲状腺疾病、恶性贫血和
红斑狼疮）相关的主要易感基因。
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Patients already affected by the following diseases are more prone to develop vitiligo (and
vice versa):
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患下列疾病的患者更容易发展成白癜风（反 之亦然）：
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Alopecia areata Pernicious anemia IgA selective defect
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斑秃、恶性贫血、IgA 选择性缺陷
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Thyroid
autoimmune disease
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自身免疫性甲状腺疾病
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Addison’s
disease
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Addison 病。
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Congenital melanocytic neviMELAS syndrome (mitochondrial encephalomyopathy, lactic acidosis, and stroke
episodes syndrome).
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先天性黑素细胞的 neviMELAS
综合征（线粒
体脑肌病、乳酸中毒、中风发作综合征）
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Stressful life events, probably interfering with the psycho-neuro-endocrine-immune system, and physical
traumas of skin, including solar burns, may easily
promote vitiligo onset in predisposed
subjects.
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应激性生活事件可能干扰心理-神经-内分 泌-免疫系统；另外皮肤物理性损伤，包括 日光灼伤，很容易诱发易感染人群发生白癜
风。
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